Ms Klobuchar, a former prosecutor, said she was running for "everyone who wanted their work recognised".
She won praise for grilling Supreme Court Justice Brett Kavanaugh and attorney general nominee William Barr during recent confirmation hearings.
The 58-year-old enters an increasingly crowded field of Democrats competing to challenge President Donald Trump.
Ms Klobuchar called on people to join her "home-grown" campaign, saying, "I don't have a political machine. I don't come from money. But what I do have is this: I have grit."
Read MORE
BBC NEWS