Chief executive Dave Brandon said it was a "profoundly sad day" for the retailer.
The giant toy-store chain was already in the process of closing one fifth of its shops after filing for bankruptcy protection last year.
Toys R Us will also close all its UK stores by the end of April.
The UK collapse will put more than 3,000 people out of work as a dismal period for the retail sector continues.
However, the company said it could resurrect 200 of the best-performing US stores if talks to combine these with its Canadian operations prove successful.
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