She passed away at home with family members by her side, said her son Anderson Cooper, a CNN anchor, after suffering from stomach cancer.
Vanderbilt, known as the "poor little rich girl", was the great-great-granddaughter of Cornelius Vanderbilt, a 19th Century tycoon.
The socialite, who was married several times, made her name in the 1970s and '80s as a designer jeans pioneer.
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